WMDA – Basic Level course

Introduction

If you’ve just started to work in the field of haematopoietic stem cell transplantation, chances are you will be overwhelmed with a lot of new information, field-specific terminology and many abbreviations. The WMDA Basic level course can support you to get a profound background and basic knowledge on subjects like donor selection, indications for stem cell transplantation and the biology behind the procedures. This course is especially valuable for everyone who starts working in this field, but it can also be a nice refresher when you’ve already worked as a donor recruiter, donor/transplant/search coordinator, laboratory technician, nurse, physician, or any other donor registry supporting positions for some years.

Who can participate?

The course has proven to be valuable for all people working in the field of stem cell transplantation, like laboratory technicians, nurses, physicians, or people with other registry supporting functions. For search coordinators and other professionals involved in stem cell donor selection, the course is almost considered mandatory to get a profound background for performing donor searches and to get a standardised level of expertise. If you are a donor coordinator, please also take a look at our special Donor Coordinator packages.

Course Summary

If you sign up for the total course, you will receive access to 9 modules and a final exam. It is also possible to purchase selected modules only. Each module is open for 3 weeks. Each module has a 1-hour lecture accompanied by a hand out, a glossary and finishes with a multiple-choice test. Depending on your educational background, you will spend around 3-5 hours per module. The speakers in the WMDA Basic Level are experts with many years of experience in research, clinical testing, patient care and knowledge of the field of haematopoietic stem cell transplantation. The Basic level course starts twice a year in January and October. If you have a (new) employee who would like to start at another date, please contact us for the possibilities.

You can also follow the accelerated version of the course. This course starts in January and finishes in June. During this accelerated version, each module will be open for 2 weeks.

At the bottom of this page you will find the details about the modules. Have a look to see what fits best with your professional expertise.

Course Setup for 2019-2020

The WMDA Basic level course is based on a 9‐month subscription for the total course, starting in October 2019. After finishing the modules, you will receive a certificate as proof of your participation.

Pricing

For EBMT/EFI/ WMDA members/staff members of WMDA member registries:
Per module € 107
Total course € 637
For non‐members:
Per module € 215
Total course € 1,071

Prices are excluding VAT.

An invoice will be sent in the first week of September to all persons who have registered for the course. This invoice has to be paid before the start of the course in October in order to participate*.

How to register for the Basic level total course or selected modules?

You can register by clicking on the ‘Register yourself’ button below and by filling out the form. During the registration procedure, we ask you to provide the details of a supervisor. We need these details to ensure approval of time and costs for your participation.  We will use your supervisor’s details in case we cannot reach you personally.

You can find the terms and conditions here: WMDA Terms and Conditions

Register yourself

Questions?

For your specific questions about the WMDA – Basic level course or when you have a (new) employee who would like to start the course at another date, you can contact the WMDA office education (education@wmda.info).
 

 

*Without timely payment, participation is not permitted.

 

Detailed Content Information

   Cells and Haematopoietic System

Description

In this module you will learn more on the different types of stem cells, like embryonic and adult stem cells, and the differentiation of these stem cells into diverse cell types. The haematopoietic stem cells are discussed in more detail as well as their role and all blood cells and components that derive from these stem cells. Furthermore, the module describes diseases that arise from the haematopoietic stem cell lineage, the scientific basis behind haeamtopoietic stem cell transplantation, and the different sources with their pros and cons.

Learning objectives

  • Describe the role of stem cells in humans and discuss their potential roles in regenerative medicine
  • List the different levels of potency of cells and describe the ability of each level to differentiate into various cell types
  • Describe the hematopoietic niche
  • Diagram the cellular components of blood and their origin from hematopoietic stem cells
  • List diseases that arise within the HSC lineage
  • List the three sources of HSC used in transplantation
Speaker Enric Carreras. MD. PhD
Affiliation REDMO. José Carreras Foundation, Barcelona, Spain
Target Audience   Search coordinators, donor coordinators, transplant coordinators, professionals involved in donor selection, donor recruiters, nurses, physicians, laboratory technicians, other registry supporting positions.

 

   Medical Basics of Haematopoietic Stem Cell Transplantation

Description

This module describes the transplant procedures, including transplant indications, the preparatory treatments of the patient, post-transplant complications (like graft failure, Graft versus Host Disease, infection, relapse) and the importance of follow-up and monitoring of late post-transplant effects on the patient.

Learning objectives

  • List diseases that are commonly treated by transplantation
  • List patient-specific factors besides disease that are considered when evaluating a patient for transplant
  • Describe the transplant procedure
  • List and define post-transplant complications and how they are often treated
  • List long term issues that may impact patients with transplants
  • Discuss the importance of collecting clinical data on transplant treatment and outcome
Speaker Bronwen E. Shaw, MBChB, PhD
Affiliation CIBMTR, Milwaukee, USA
Target Audience   Search coordinators, donor coordinators, transplant coordinators, professionals involved in donor selection, donor recruiters, nurses, physicians, laboratory technicians, other registry supporting positions.

 

   Registries and Cord Blood Banks

Description

This module gives a general overview of the function and role of donor registries and cord blood banks, how they communicate and the different IT tools available during the search process. Also, information is provided about haematopoietic stem cell transplantation supporting umbrella organisations, like WMDA, EBMT, and WBMT. In order to promote quality in haematopoietic stem cell transplantation and the international exchange of donors and cord blood unit, a number of organisations provide accreditation of the various activities and also other regulations impacting cellular therapy and donor information exchange.

Learning objectives

  • Describe the organisational structure of the entities that support transplantation with unrelated volunteer donors and cord blood units
  • Appreciate the current status of the international donor pool and the donor exchange activity worldwide
  • Explain the purpose and role of worldwide organisations that support unrelated donor exchange
  • Be aware of regulatory activities governing donor exchange
Speaker Evelyne Marry, MD
Affiliation Hematopoietic Stem Cell Department, Agence de la Biomédecine, Saint-Denis La Plaine Cedex, France
Target Audience   Search coordinators, donor coordinators, transplant coordinators, professionals involved in donor selection, donor recruiters, nurses, physicians, laboratory technicians, other registry supporting positions.

 

   The Donor Experience

Description

This module provides more information on the procedures around registration, donation and follow-up from a donor’s perspective. We are usually focused on curing patients, but the donors health needs to be protected as well with for example the WMDA standards and informed consents. The donor experience after donation might have direct impact on the matched patient and on the donor registry.

Learning objectives

  • Characteristics of stem cell donors
  • Stages in donor selection: recruitment, CT (verification and extending typing), workup, donation, follow-up
  • Protection of the donor (voluntary nature, informed consent, multiple donation requests)
Speaker Anne-Marie van Walraven, PhD
Affiliation Sanquin Donor Services, Amsterdam, The Netherlands
Target Audience   Search coordinators, donor coordinators, transplant coordinators, professionals involved in donor selection, donor recruiters, nurses, physicians, laboratory technicians, other registry supporting positions.

 

   Basic Concepts in Immunology

Description

Haematopoietic stem cell transplantation is a treatment for diseases that affect the immune system, but the immune system is also a major barrier to transplantation of tissues from one individual to another. Therefore, it is very important to understand the basics of our immunology system, like the organs and cells that are involved, how the immune system recognises self and non-self cells, how immune cells communicate, and the early (innate) and late onset (adaptive) responses of the immune system to ‘danger’. Also the basic concepts of transplantation immunology are described, including graft rejection and Graft versus Host Disease.

Learning objectives

  • Define self vs non-self
  • Identify organs and cells of the immune system and their general functions
  • List the general characteristics of the innate and adaptive immune responses
  • Describe how non-self is detected by B and T lymphocytes
  • Describe basic ‘laws’ of transplantation
Speaker Carolyn Hurley, PhD, D(ABHI)
Affiliation Department of Oncology, Georgetown University, Washington DC, USA
Target Audience   Search coordinators, donor coordinators, transplant coordinators, professionals involved in donor selection, donor recruiters, nurses, physicians, laboratory technicians, other registry supporting positions.

 

   Basic Genetics of HLA

Description

The HLA proteins on the cells are of significance in the haematopoietic stem cell transplantation. These HLA proteins are inherited by your parents and therefore it is also important to understand the basic concepts of genetics besides the basics of immunology. This module describes where you can find the genetic material coding for the HLA proteins, but also definitions like haplotype and diplotype, homozygous and heterozygous, recombination and mutations. Understanding population genetics can be useful in the search for an unrelated donor for your patient and calculations based on this can help to predict if a certain donor might be a match.

Learning objectives

  • Understand the role of DNA and proteins
  • Define the basic terminology of genetics
  • Understand the inheritance of HLA genes
  • Describe how the diversity in the HLA system arose
  • Describe the importance of population genetics in finding an HLA matched donor
Speaker Carlheinz Müller, MD, PhD
Affiliation ZKRD, Ulm, Germany
Target Audience   Search coordinators, donor coordinators, transplant coordinators, professionals involved in donor selection, donor recruiters, nurses, physicians, laboratory technicians, other registry supporting positions.

 

   Human Leukocyte Antigens (HLA)

Description

HLA matching is very important in the selection of stem cell donors, but why is this? In this module you learn about the role of HLA in the immune response against foreign tissues, the differences between HLA class I and class II and why we find so much HLA diversity in the human population. Also the influence of HLA in some diseases, like infectious diseases and auto immune diseases are explained as well as the interaction of HLA in drug toxicities.

Learning objectives

  • Describe the role that HLA plays in immune response to pathogens
  • Compare and contrast the properties of the HLA class I and class II proteins
  • Identify the most important components of an HLA allele name when selecting a matched donor
  • Describe an HLA haplotype and how knowledge of allele associations plays a role in the search for a matched donor
  • Describe situations where HLA plays a part in the risk of a disease or in its treatment
Speaker Carolyn Hurley, PhD, D(ABHI)
Affiliation Department of Oncology, Georgetown University, Washington DC, USA
Target Audience   Search coordinators, donor coordinators, transplant coordinators, professionals involved in donor selection, donor recruiters, nurses, physicians, laboratory technicians, other registry supporting positions.

 

   HLA Matching

Description

This module focuses on selection of HLA matched haematopoietic stem cell donors. The first choice of donor is usually a related family member, followed by an unrelated donor or cord blood unit. However, HLA compatibility is always the most important criterium for matching. Some HLA alleles can be predicted based on the HLA-B-C and HLA-DRB1-DQB1 associations. These HLA alleles and haplotype frequency estimations can be found in several (online) databases. Do you know how to interpret survival curves, odds ratios, confidence intervals and hazard ratios? You  learn this when the clinical impact of transplantations with HLA mismatched donors or cord blood units is discussed in this module.

Learning objectives

  • Define and describe HLA compatibility
  • Define and describe linkage disequilibrium and multiple mismatches
  • Define HLA matching criteria (unrelated donors)
  • List the impact of HLA mismatches in transplantation with HSC from unrelated donors
  • Other donor selection criteria
  • List impact of HLA mismatches in transplantation with HSC from CBUs
Speaker Jean-Marie Tiercy, PhD
Affiliation Department of Genetics and Laboratory Medicine, University Hospital, Geneva, Switzerland
Target Audience   Search coordinators, donor coordinators, transplant coordinators, professionals involved in donor selection, donor recruiters, nurses, physicians, laboratory technicians, other registry supporting positions.

 

   Search Strategy and Web Tools for Search

Description

Always wanted to know how search coordinators find the best matched donor for the patients? This module explains how you should start a search for a stem cell donor by evaluating the patient’s HLA, how to interpret search reports and select potentially matched donors for further testing. During the donor search, you can use many different web tools to evaluate the HLA of the patient or predict the HLA genotype and haplotypes from the potential donors. When and how to use those web tools is explained in this module as well as in the WMDA search tools guide.

Learning objectives

  • Define and describe how to carry out an effective unrelated donor search
  • Evaluate a patient’s HLA by using web-based tools
  • Interpret an unrelated donor search report and select potentially matching donor from search report
  • Select mismatched donors based on data from outcome studies
Speakers Machteld Oudshoorn, PhD and Carolyn Hurley, PhD, D(ABHI)
Affiliation Matchis Foundation and Department of Immunohematology and Blood Transfusion, Leiden University Medical Centre, Leiden, The Netherlands
Department of Oncology, Georgetown University, Washington DC, USA
Target Audience   Search coordinators, donor coordinators, transplant coordinators, professionals involved in donor selection, donor recruiters, nurses, physicians, laboratory technicians, other registry supporting positions.